病理状态可影响和改变机体的某些功能,病理状态对药物的吸收、代谢、分布,与蛋白质结合、排泄以及药效等都可发生影响。掌握此规律,对在病理状况下选药、用药是十分有益的。止痛退热剂对正常体温几无影响,但对发热病人则有明显退热作用;利尿剂对正常人几无明显影响,但对水肿病人则产生显著的利尿消肿作用;有机磷中毒病人,对阿托品的用量就比正常人大若干倍(几倍至几十倍)。病理状态从以下 Pathological conditions can affect and change some of the body’s functions, pathological state of the drug absorption, metabolism, distribution, and protein binding, excretion and efficacy can be affected. Master this rule, the choice of medicine in the pathological conditions, medication is very useful. Analgesic antipyretics had no effect on the normal body temperature, but there was a significant antipyretic effect on febrile patients; diuretics had no significant effect on normal people, but the edema patients have significant diuretic swelling; organic phosphorus poisoning patients, The amount of atropine on the number of times larger than normal (several times to several times). Pathology from the following