鼻腔粘膜下填塞术治疗萎缩性鼻炎,远在19世纪末(1894)Sanger氏首先应用金属作鼻粘膜下填塞物,以达到缩窄鼻腔的目的。自1900年Gersung氏在鼻粘膜下注入石腊后,开僻了鼻粘膜下填塞术。但由于石腊易被吸收,故疗效不持久,以后许多学者采用象牙、牛骨、羊骨、肠骨、肋软骨、鼻中隔软骨、肌腱、玻璃、赛璐珞等作为填塞物。1942年Guttierez氏首先应用胶脂(即一种丙烯树脂Acrylia Nasal submucosal tamponade for the treatment of atrophic rhinitis, far in the late 19th century (1894) Sanger’s first use of metal for nasal submucosal stuffing in order to achieve the purpose of narrowing the nose. Since 1900, Gersung’s nasal submucosal injection of paraffin, open the nasal submucosal packing. However, since paraffin wax is easily absorbed, its curative effect is not long-lasting. Since then, many scholars use ivory, bovine bone, sheep bone, iliac bone, costal cartilage, nasal septum cartilage, tendons, glass and celluloid as a stuffing. 1942 Guttierez’s first application of plastic grease (that is, an acrylic resin Acrylia