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目的观察复方异丙托溴铵液雾化吸入治疗慢阻肺急性加重期的疗效。方法 2012年6月—2014年6月对住院慢阻肺急性加重期患者188例,随机分对照组与研究组各94例,对照组给予常规基础治疗,研究组除常规治疗外加用复方异丙托溴铵液雾化吸入,观察两组治疗前后的呼吸困难程度、动脉血气指标、症状、体征缓解时间及不良反应情况。结果治疗7d后,研究组的有效率、呼吸困难评分、血气指标改善等明显优于对照组;研究组治疗后的咳嗽缓解时间、喘息、肺部体征消失时间均明显短于对照组,差异均有统计学意义(P<0.05)。结论常规治疗联合复方异丙托溴铵液雾化吸入治疗慢阻肺急性加重期疗效确切,值得临床推广应用。
Objective To observe the curative effect of compound ipratropium bromide liquid inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods From June 2012 to June 2014, 188 patients with acute obstructive pulmonary disease in hospital were randomly divided into control group and study group (n = 94). The control group was given routine basic treatment. In addition to routine treatment, Inhaled inhalation of bromine bromide liquid, observed the degree of dyspnea before and after treatment, arterial blood gas index, symptoms, symptom relief time and adverse reactions. Results After 7 days of treatment, the effective rate, dyspnea score, and improvement of blood gas indexes in the study group were significantly better than those in the control group. The cough remission time, wheezing and disappearance of lung signs in the study group were significantly shorter than those in the control group There was statistical significance (P <0.05). Conclusion Conventional treatment combined with ipratropium bromide solution atomization inhalation for the treatment of acute exacerbation of COPD is effective and worthy of clinical application.