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为了探讨围产期沙眼衣原体(CT)感染与不良妊娠结局、母婴间的垂直传播及对受染儿的远期影响等问题,我们以直接免疫荧光法、金标法对200例临产妇、25例新生儿(母亲CT抗原阳性),进行了CT抗原检测。结果如下:兰州地区产妇中CT的感染率平均为12.5％,母婴间的垂直传播率为40％,产妇感染CT与胎儿早产、出生低体重有相关性。CT在早产儿、低出生体重儿、新生儿窒息者中母婴垂直传播率高于正常足月儿;母婴垂直传播所致受染新生儿今后呼吸系统疾病的感染率高于未受感染儿;直接免疫荧光法、金标法,对CT抗原都是比较准确、快速的检测方法,可以作为早期诊断手段。特别是金标法,更利于在临床中应用、推广围产期沙眼衣原体感染的研究。
In order to explore the perinatal period of Chlamydia trachomatis (CT) infection and adverse pregnancy outcomes, the vertical transmission between mother and child and the long-term effects on the infected children and other issues, we use direct immunofluorescence method, gold standard 200 cases of maternal, Twenty-five newborns (mothers with positive CT antigen) were tested for CT antigen. The results are as follows: The average infection rate of CT in Lanzhou was 12.5%, and the vertical transmission rate between maternal and infant was 40%. Maternal infection CT was associated with premature birth and low birth weight. The rate of mother-to-child vertical transmission was higher in preterm infants, low birth weight infants, and neonatal asphyxia than those in normal term infants. The prevalence of respiratory diseases in newborns infected by vertical transmission of mother and baby was higher than that of non-infected infants ; Direct immunofluorescence, gold standard method, CT antigen are more accurate and rapid detection method, can be used as an early diagnosis. Especially gold standard method, more conducive to the clinical application of the promotion of perinatal Chlamydia trachomatis infection.