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【病例简介】女,49岁。主因四肢皮肤硬肿10年,全身色素沉着5年,气短、腹胀1周入院。患者10年前出现双下肢及双眼睑水肿,2008-2009年曾于某三甲医院查肾功能、皮质醇、促肾上腺皮质激素均正常,尿常规:尿潜血(+~++),尿蛋白可疑阳性;24 h尿蛋白定量0.3 g。2010年逐渐出现四肢皮肤变硬肿胀,伴全身色素沉着、四肢关节肿痛,于某医院查抗核抗体滴度1:80,
[Case description] Female, 49 years old. Mainly due to limbs, skin sclerosis 10 years, 5 years of systemic pigmentation, shortness of breath, abdominal distension 1 week admission. Patients with lower extremities and double eyelid edema 10 years ago, 2008-2009 had a top three hospitals in the investigation of renal function, cortisol, adrenocorticotropic hormone were normal, urinary routine urinary occult blood (+ ~ +), urinary protein suspicious Positive; 24 h urine protein quantitative 0.3 g. 2010 gradual emergence of limbs, skin hardening and swelling, with body pigmentation, joint swelling and pain in the limbs, check anti-nuclear antibody titers 1:80 in a hospital,