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近期一些报告已经提出了合成代谢类固醇药物疗法与肝肿瘤和肝瘤样病变之间的可能关系。多数报告为肝细胞癌。少数报告为肝细胞腺瘤,增生结节或分化良好的肝细胞癌。而本文报告一例用合成代谢激素治疗三年发生肝内胆管癌。本报告为一例47岁,男性病人因顽固性大细胞贫血,使用合成代谢类固醇化合物(oxymetholone)治疗。剂量每日100 mg～300mg,三年后因右上腹痛肝功能异常住院治疗,不久死亡。经尸检证实为肝内胆管癌,同时有腹腔淋巴结和肺的转移。作者复习了他人报告的26例与合成代谢激素治疗有关的肝肿瘤病例,多因患Fanconi’s贫血,再生不良贫血、其他血液病和内分泌失调病。服药时间有明
Some recent reports have suggested a possible relationship between anabolic steroid drug therapy and liver tumors and liver tumor-like lesions. The majority of reports are hepatocellular carcinoma. A small number of reports of hepatocellular adenoma, hyperplastic nodules or well-differentiated hepatocellular carcinoma. This article reports a case of intrahepatic cholangiocarcinoma with anabolic hormone therapy for three years. This is a case report of a 47-year-old male patient treated with oxymetholone due to refractory macrocytic anemia. Dose 100 mg ~ 300mg daily, three years after the right upper quadrant liver function abnormal hospitalized, soon died. After the autopsy confirmed intrahepatic cholangiocarcinoma, with abdominal lymph node and lung metastasis. The authors reviewed 26 other reported cases of liver tumors associated with anabolic hormonal therapies reported by others, mostly due to Fanconi’s anemia, aplastic anemia, other blood diseases, and endocrine disorders. Medication time is bright