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目的观察银杏叶提取物（ＥＧＢ）对小鼠缺氧及缺氧性记忆障碍的影响。方法采用ＮａＮＯ２、ＫＣＮ及断头等方法造成小鼠缺氧致死模型。以ＮａＮＯ２造成小鼠缺氧性记忆缺失模型，并用跳台法作行为检测，ＴＢＡ法测定丙二醛（ＭＤＡ）含量，Ｇｒｅｅｎ法测定ＮＯ含量。结果ＥＧＢ（４０，８０ｍｇ·ｋｇ－１，ｉｇ，ｑｄ×１４天）可使以上模型缺氧小鼠的存活时间延长；减少记忆缺失小鼠的跳台错误次数，延长其ＳＤＬ，并使脑组织中升高的ＭＤＡ和ＮＯ含量降低。结论ＥＧＢ有明显的耐缺氧作用；对ＮａＮＯ２引起的缺氧性记忆障碍有明显改善，此作用可能与脑组织ＭＤＡ、ＮＯ含量的变化有一定关联。
Objective To observe the effects of Ginkgo biloba extract (EGB) on hypoxia and hypoxic memory impairment in mice. Methods NaNO2, KCN and decapitation were used to induce hypoxia-induced death in mice. The model of hypoxia-induced memory loss in mice was induced by NaNO2, and the behavior was determined by the method of step-down. The content of malondialdehyde (MDA) was measured by TBA method and the content of NO was determined by Green method. Results EGB (40, 80 mg·kg-1, ig, qd × 14 days) prolonged the survival time of hypoxic mice in the above model; reduced the number of stage errors in mice with memory deficit, prolonged their SDL, and made brain tissue Increased MDA and NO levels are reduced. Conclusions EGB has obvious anti-hypoxia effect; it can significantly improve the hypoxic memory impairment caused by NaNO2. This effect may be related to the changes of MDA and NO in brain tissue.