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目的:探讨宫腔形态无改变的肌壁间子宫肌瘤对体外受精/卵胞质内单精子注射-胚胎移植(in vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)临床结局的影响。方法:选择行IVF/ICSI-ET治疗伴单发或多发肌壁间子宫肌瘤且宫腔形态正常的93例不孕症患者作为研究对象,共行胚胎移植104个周期(研究组);按对照组与研究组1:3比例随机抽取同期行IVF/ICSI-ET且无子宫肌瘤的308例患者作为对照组,共行IVF/ICSI-ET周期312个,分析控制性超促排卵(COH)、体外受精参数和妊娠结局。结果:研究组患者的年龄、不孕年限显著高于对照组(P<0.05),促性腺激素(Gn)使用天数、获卵数显著低于对照组(P<0.05);体质量指数(BMI)、Gn用量、双原核(2PN)率、卵裂率、优质胚胎率、临床妊娠率、着床率、异位妊娠率、早期流产率、晚期流产率、活产率、单胎活产率、双胎活产率、早产率、低体质量儿率、出生缺陷率组间均无统计学差异(P>0.05)。结论:宫腔形态无改变的肌壁间子宫肌瘤对IVF-ET的临床结局无明显不良影响。
Objective: To investigate the effect of uterine fibroids with unchanged uterine cavity on clinical outcome of in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) . Methods: A total of 93 infertility patients with single or multiple intramural uterine fibroids and normal uterine cavity morphology were enrolled in this study. 104 embryos (study group) 308 patients with IVF / ICSI-ET and no uterine fibroids in the control group and the study group were randomly selected as the control group, with 312 cycles of IVF / ICSI-ET in total. 312 patients underwent controlled ovarian hyperstimulation (COH) ), In vitro fertilization parameters and pregnancy outcome. Results: The age and duration of infertility in the study group were significantly higher than those in the control group (P <0.05). The number of gonadotrophin (Gn) days and the number of oocytes retrieved were significantly lower than those in the control group (P <0.05). The body mass index ), Gn dosage, 2PN rate, cleavage rate, high quality embryo rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, early abortion rate, late abortion rate, live birth rate, single live birth rate , Twin live birth rate, premature birth rate, low birth weight rate, birth defects rate between the two groups had no statistical difference (P> 0.05). Conclusion: Uterine fibroids without intrauterine morphological changes have no significant adverse effect on the clinical outcome of IVF-ET.