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目的为提高临床胚胎移植妊娠率,临床对长、短方案使用促性腺激素释放激素激动剂(Gn RH-a)在体外受精-胚胎移植中应用可行性进行研究。方法 70例不孕症患者入院行体外受精-胚胎移植治疗,按双盲法随机分为观察1组与观察2组,每组35例。观察1组使用长方案,观察2组使用短方案,所有胚胎均经玻璃化。观察两组患者临床妊娠情况,同时记录入院时、注射人绒毛膜促性腺激素(HCG)前患者血清性激素水平。结果入院时观察1组卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)检测水平低于观察2组(P<0.05);注射HCG前观察1组LH、E2水平低于观察2组(P<0.05)。观察1组临床妊娠率42.9%高于观察2组17.1%(P<0.05)。结论长方案使用Gn RH-a用于体外受精-胚胎移植,患者临床妊娠率高于短方案。
Objective To improve the pregnancy rate of clinical embryo transfer, the feasibility of long-term and short-term gonadotropin-releasing hormone agonist (Gn RH-a) in vitro fertilization-embryo transfer was studied. Methods 70 cases of infertility patients admitted to in vitro fertilization and embryo transfer treatment were randomly divided into observation group 1 and observation group 2 by double-blind method, 35 cases in each group. A long protocol was observed in group 1, and a short protocol was used in both groups. All embryos were vitrified. The clinical pregnancy status was observed in both groups. At the same time, the levels of serum sex hormone in patients with HCG before admission were recorded. Results The levels of FSH, LH and E2 were lower in observation group 1 than those in observation group 2 before admission (P <0.05). The levels of LH and E2 in group 1 were observed before HCG injection Two groups were observed (P <0.05). The observation group 1 clinical pregnancy rate was 42.9% higher than the observation group 2 17.1% (P <0.05). Conclusions The long protocol used Gn RH-a for in vitro fertilization-embryo transfer, with a higher clinical pregnancy rate than the short protocol.