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目的探讨血、尿β2-微球蛋白(β2-MG)、а1-微球蛋白(а1-MG)检测对2型糖尿病早期肾病的诊断价值。方法采用放射免疫法测定94例2型糖尿病患者和25例正常体检者的尿微量白蛋白排泄率(UAER),血、尿β2-MG和а1-MG。结果肾功能不全组、显性蛋白尿组、微量白蛋白阴性组与微量白蛋白组比较,除血β2-MG在微量白蛋白阴性和微量白蛋白组之间差异无统计学意义,其余差异均有统计学意义。结论尿β2-MG,血、尿а1-MG对2型糖尿病早期肾病有诊断价值,血β2-MG对2型糖尿病早期肾病无诊断价值。
Objective To investigate the diagnostic value of blood and urinary β2-microglobulin (β2-MG) and а1-microglobulin (а1-MG) in type 2 diabetic patients with early nephropathy. Methods The urinary albumin excretion rate (UAER), blood and urine β2-MG and а1-MG were measured in 94 patients with type 2 diabetes mellitus and 25 normal subjects by radioimmunoassay. Results Compared with microalbumin group, renal dysfunction group, dominant proteinuria group and microalbuminuria group showed no significant difference in serum β2-MG between microalbumin group and microalbumin group, while the other differences were significant There is statistical significance. Conclusion Urinary β2-MG, blood and urinary а1-MG have diagnostic value in type 2 diabetic nephropathy. Serum β2-MG has no diagnostic value in type 2 diabetic nephropathy.