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目的分析烧伤患者血浆前列腺素E2、肿瘤坏死因子水平的变化程度。方法按照临床科研方法设计试验方案,将笔者单位收治30例烧伤患者作为研究对象,按照烧伤面积、有无脓毒症进行分组,并设置对照组,借助酶联吸附、放射免疫分析法进行检测,以评定患者不同时间点的血浆前列腺素E2、肿瘤坏死因子水平。结果患者烧伤后部分可呈现血浆前列腺素E2水平升高现象,但大面积烧伤者、脓毒症者血浆前列腺素E2则降低,且降低程度低于正常值,P<0.05;患者烧伤后肿瘤坏死因子水平升高,脓毒症期间更加明显。结论烧伤后的血浆前列腺素E2水平不存在均一性,肿瘤坏死因子水平降低者易引发脓毒症,需引起高度重视。
Objective To analyze the changes of plasma prostaglandin E2 and tumor necrosis factor level in burn patients. Methods According to the clinical scientific research methods, the experimental plan was designed. The 30 patients with burn treated by the author were selected as the research objects. The patients were divided according to the burn area and the presence or absence of sepsis. The control group was set up and detected by enzyme-linked immunosorbent assay and radioimmunoassay. To assess the patient at different time points of plasma prostaglandin E2, tumor necrosis factor level. Results The level of plasma prostaglandin E2 was increased in the burn patients, but the plasma prostaglandin E2 was decreased in severe burn patients and in sepsis patients, and the degree of plasma prostaglandin E2 was lower than the normal value (P <0.05). The tumor necrosis Elevated levels of factors, more obvious during sepsis. Conclusion There is no homogenization of plasma prostaglandin E2 level after burns, and those with decreased levels of tumor necrosis factor (TNF) are apt to cause sepsis.