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用PCR和ELISA技术对38例AA患儿的外周血进行了B 19、EBV、CMV及HBV系列检测。结果:(1)病例组B 19-DNA阳性9例(23.7％),与正常对照比较差异有非常显著性意义(P=0.00871),EBV-DNA阳性1例,HBsAg和HBeAg同时阳性者2例,上述病毒的总阳性率为31.6％(12/38例)。(2)将B 19阳性9例按AAA和CAA进一步比较,两者无显著性差异(P=0.673)。提示:(1)近1/3AA病例的发生可能与上述病毒感染有关。而B 19较其他病毒与AA的关系更为密切。(2)B 19感染与AAA和CAA的发生均有关。(3)HBV仍为我国HAAA的重要病因,EBV可能为儿童获得性AA的病毒病因之一。
Peripheral blood samples from 38 children with AA were tested for B 19, EBV, CMV and HBV by PCR and ELISA. Results: (1) There were 9 cases (23.7%) positive for B 19-DNA in case group, which was significantly different from the normal control group (P = 0.00871), 1 case was positive for EBV-DNA, 2 cases were positive for HBsAg and HBeAg The total positive rate of these viruses was 31.6% (12/38 cases). (2) There was no significant difference between the two groups (P = 0.673). Tip: (1) The incidence of 1 / 3AA cases may be related to the above virus infection. B 19 is more closely related to AA than other viruses. (2) B 19 infection is related to the occurrence of AAA and CAA. (3) HBV is still an important cause of HAAA in our country, and EBV may be one of the etiological agents of childhood acquired AA.