论文部分内容阅读
目的观察小剂量氢氯噻嗪与厄贝沙坦联合治疗轻、中度原发性高血压的疗效。方法选择符合标准的120例轻、中度原发性高血压患者口服氢氯噻嗪12.5mg,每日一次,厄贝沙坦75mg或150mg,每日一次,疗程8周。观察其降压疗效及安全性。结果经过8周的治疗,收缩压/舒张压较治疗前分别降低(18.30±10.55)/(13.21±7.47)mmHg,8周末总有效率为80.8%;治疗后收缩压和舒张压的T/P比值分别为79.5%和83.8%,不良反应主要有血尿酸升高、头晕、低血钾、血肌酐偏高,均为轻度。结论小剂量氢氯噻嗪与厄贝沙坦联用能够持续平稳有效地降低24小时血压,而且安全性良好。
Objective To observe the curative effect of low dose hydrochlorothiazide combined with irbesartan on mild to moderate essential hypertension. Methods 120 patients with mild to moderate essential hypertension were treated with hydrochlorothiazide 12.5 mg once daily and 75 mg or 150 mg irbesartan once daily for 8 weeks. Observe its antihypertensive efficacy and safety. Results After 8 weeks of treatment, systolic blood pressure and diastolic blood pressure decreased (18.30 ± 10.55) / (13.21 ± 7.47) mmHg, respectively, and the total effective rate at 8 weeks was 80.8%. After treatment, the systolic and diastolic blood pressure T / P The ratios were 79.5% and 83.8% respectively. The main adverse reactions were hyperuricemia, dizziness, hypokalemia and high serum creatinine, all of which were mild. Conclusions Low-dose hydrochlorothiazide combined with irbesartan can reduce the 24-hour blood pressure smoothly and effectively, and its safety is good.