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本文研究了血管紧张素转移酶抑制剂立西普利(Lis)和卡托普利(Cap)对离体大鼠心脏缺血再灌引起损伤的保护作用。实验证明Lis 100nmol/L和Cap 200μmol/L能明显降低心肌组织中丙二醛(MDA)的含量,保护超氧化物歧化酶(SOD)的活性。此外,这两种转移酶抑制剂均能升高心肌组织中前列环素(PGI_2)和谷胱甘肽(GSH)的含量。表明它们对心肌缺血再灌损伤均具明显的保护作用。
This study investigated the protective effect of angiotensin transferase inhibitors Lis and Cap on the injury induced by ischemia-reperfusion in isolated rat hearts. Experiments show that Lis 100nmol / L and Cap 200μmol / L can significantly reduce myocardial tissue malondialdehyde (MDA) content, protect the activity of superoxide dismutase (SOD). In addition, both of these transferase inhibitors increased the content of prostacyclin (PGI_2) and glutathione (GSH) in myocardium. Show that they have a significant protective effect on myocardial ischemia-reperfusion injury.