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Jacobson 等首先报道在中期妊娠时抽取羊水用来作遗传疾病的产前诊断,但往往由于抽得的胎儿细胞的数量过少,不够用来作为诊断分析而造成失败。根据香港大学医学系陈棣光(T.K.Chan)和陈立怡(V.
Jacobson first reported that during the second trimester, amniotic fluid extraction was used as a prenatal diagnosis of genetic diseases, but often due to the small number of fetched fetal cells, it was not enough to be used as a diagnostic test to cause failure. According to University of Hong Kong’s Department of Medicine, T. K. Chan and Chen Liyi