目的检测食管癌患者血清中血管内皮生长因子（VEGF）水平并探讨其临床意义。方法用ELISA方法检测38例食管癌和82例正常人群血清中VEGF165的浓度。结果正常健康人血清中存在VEGF165，其正常值为0．188μg／L，食管鳞癌者血清中VEGF水平明显高于正常对照组，血清VEGF水平随着食管临床病理分期的进展而逐步升高。结论VEGF血清水平在一定程度上反映食管癌患者的临床病理分期，有利于对治疗措施的选择和预后的判断。 Objective To detect the serum level of vascular endothelial growth factor (VEGF) in esophageal cancer patients and explore its clinical significance. Methods ELISA was used to detect the serum VEGF165 concentration in 38 cases of esophageal cancer and 82 normal people. Results VEGF165 was present in normal healthy human serum. The normal value was 0.188 μg/L. The serum VEGF level in esophageal squamous cell carcinoma patients was significantly higher than that in the normal control group. Serum VEGF levels increased gradually with the progression of the clinical pathological stage of the esophagus. Conclusion The serum level of VEGF reflects the clinicopathological stage of patients with esophageal cancer to a certain extent, which is conducive to the choice of therapeutic measures and the judgment of prognosis.