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基于头孢氨华（ＣＥＸ）降解产物中含有巯基（－ＳＨ），能与Ａｇ＋生成难溶化合物的特性，在银微盘电极上研究了ＣＥＸ降解产物的伏安行为，探讨了电极反应的机理。运用示差脉冲溶出伏安法，在０．１ｍｏｌ／Ｌ ＨＡｃ－ＮａＡｃ介质中，ＣＥＸ降解产物的还原峰电流与ＣＥＸ浓度于８．０×１０－８～７．０×１０－６ｍｏｌ／Ｌ范围内呈良好线性关系；检测限为１．０×１０－８ｍｏｌ／Ｌ；测定头孢氨苄胶囊中ＣＥＸ．含量为９２．０％，与药典法比较，相对误差为３．４％。
The voltammetric behavior of CEX degradation products was studied on the silver microdisk electrode based on the properties of thiol (-SH) in the degradation products of cephalexin (CEX) and the formation of insoluble compounds with Ag +. The mechanism of electrode reaction was also discussed. Using differential pulse stripping voltammetry, the reduction peak current and CEX concentration of CEX degradation products in the 0.1 mol / L HAc-NaAc medium ranged from 8.0 × 10-8 to 7.0 × 10-6 mol / L Showed a good linear relationship; detection limit of 1.0 × 10-8mol / L; determination of cephalexin CEX. Content of 92.0%, compared with the pharmacopoeia method, the relative error of 3.4%.