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基于头孢氨华(CEX)降解产物中含有巯基(-SH),能与Ag+生成难溶化合物的特性,在银微盘电极上研究了CEX降解产物的伏安行为,探讨了电极反应的机理。运用示差脉冲溶出伏安法,在0.1mol/L HAc-NaAc介质中,CEX降解产物的还原峰电流与CEX浓度于8.0×10-8~7.0×10-6mol/L范围内呈良好线性关系;检测限为1.0×10-8mol/L;测定头孢氨苄胶囊中CEX.含量为92.0%,与药典法比较,相对误差为3.4%。
The voltammetric behavior of CEX degradation products was studied on the silver microdisk electrode based on the properties of thiol (-SH) in the degradation products of cephalexin (CEX) and the formation of insoluble compounds with Ag +. The mechanism of electrode reaction was also discussed. Using differential pulse stripping voltammetry, the reduction peak current and CEX concentration of CEX degradation products in the 0.1 mol / L HAc-NaAc medium ranged from 8.0 × 10-8 to 7.0 × 10-6 mol / L Showed a good linear relationship; detection limit of 1.0 × 10-8mol / L; determination of cephalexin CEX. Content of 92.0%, compared with the pharmacopoeia method, the relative error of 3.4%.