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采用流式细胞仪检测68例胃癌患者外周血T细胞亚群及癌组织DNA信体。与对照组相比,进展期胃癌患者外周血T细胞亚群比值防病期发展逐渐降低,与DNA二倍体癌相比,异倍体癌其T细胞亚群比值失衡更加显著。结果或可解释病理分级相同的肿瘤,临床表现其生物学行为及预后明显不同的原因。提示.化疗、免疫或基因治疗对异倍体DNA造成免疫系统严重受损的患者临床效果可能显著。
Flow cytometry was used to detect peripheral blood T cell subsets and cancer tissue DNA in 68 patients with gastric cancer. Compared with the control group, the ratio of T lymphocyte subsets in peripheral blood of patients with advanced gastric cancer was gradually reduced. The ratio of T cell subsets in the aneuploid carcinoma was more significant than that in DNA diploid carcinoma. The results may explain the same pathological grade of the tumor, clinical manifestations of its biological behavior and the prognosis is significantly different reasons. prompt. The clinical effects of chemotherapy, immunization, or gene therapy on patients with severely compromised immune systems from aneuploid DNA may be significant.