目的:研究醋酸地塞米松固体脂质纳米粒冻干粉针的体外释放规律。方法:选用0.1mol·L-1磷酸盐缓冲液(pH7.4)作为释药介质,测定并绘制其体外释放曲线,并对释药数据进行模型拟合。结果:醋酸地塞米松固体脂质纳米粒冻干粉针在0,4,12,48,168h的累计释药百分率分别为56.82%,71.67%,73.10%,85.40%;最佳拟合模型为Peppas方程。结论:醋酸地塞米松固体脂质纳米粒冻干粉针的体外释放具有突释和缓释效应。 Objective: To study the in vitro release of dexamethasone acetate solid lipid nanoparticles freeze-dried powder. Methods: 0.1mol·L-1 phosphate buffer (pH7.4) was used as the drug-releasing medium. The in vitro release curve was determined and plotted. The drug release data were fitted to the model. Results: The cumulative drug release rates of dexamethasone acetate solid lipid nanoparticles freeze-dried powder at 0,4,12,48,168h were 56.82%, 71.67%, 73.10% and 85.40%, respectively. The best fitting model was Peppas equation. Conclusion: The dexamethasone acetate solid lipid nanoparticles freeze-dried powder in vitro release with burst release and sustained release effect.