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环孢菌素是一种新型的免疫抑制剂,近年试用于肾病,对激素耐药的部分病人中取得了较好的疗效。病例和方法 (1)肾病综合征(不仅为蛋白尿),(2)激素耐药和激素依赖,(3)微小病变(MCD),(4)局灶节段小球硬化(FSGS),任何系统性疾病所致肾病(NS)均排除,初剂量5mg/kg/dag,分二次给药,全血谷值为200～860ng/ml(血清谷值为50—200ng/ml)。结果初步研究中113例病例结果分析,成人MCD18例有效,3例无效,儿童MCD37例有效,13例无效,成人FSGS 6例均有效,儿童FSGS18例有效,12例无效。先前对激素敏感但多次反复的
Cyclosporine is a new type of immunosuppressive agent, which has been tested in kidney disease in recent years and achieved good results in some patients who are resistant to the hormone. (1) nephrotic syndrome (not only proteinuria), (2) hormone resistance and hormone dependence, (3) minimal change disease (MCD), (4) focal segmental glomerulosclerosis (FSGS), any systematic Disease-induced nephropathy (NS) were excluded, the initial dose of 5mg / kg / dag, administered twice, the whole blood valley value of 200 ~ 860ng / ml (serum trough 50-200ng / ml). Results of the preliminary study of 113 cases, the results of 18 cases of MCD effective in adults, 3 cases of ineffective, 37 cases of children with MCD effective, ineffective in 13 cases of adult FSGS are valid in 18 cases of children with FSGS effective, 12 cases of ineffective. Previously hormone sensitive but repeated many times