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磁纳米粒子在分子影像学研究中扮演了极其重要的角色。第一代磁纳米粒子已经用于肝脏肿瘤的临床检测,第二代磁纳米粒子也将用于临床,比第一代有更长的血液半衰期,更小的粒径及更高的弛豫性,可用于全身多个器官、多种疾病的检测。目前,磁纳米粒子在心血管系统成像的应用中,可以通过巨噬细胞的浸润成像测量梗死的心肌范围;通过心肌细胞凋亡成像了解急性心肌损伤中细胞死亡的病理机制,通过心肌细胞坏死成像显示坏死的心肌等。
Magnetic nanoparticles play an extremely important role in molecular imaging research. The first generation of magnetic nanoparticles has been used for the clinical detection of liver tumors. The second generation of magnetic nanoparticles will also be used clinically, with longer blood half-life, smaller particle size and higher relaxation than the first generation , Can be used for multiple body organs, a variety of diseases detection. At present, magnetic nanoparticles can be used to measure myocardial infarction size in infiltration imaging of macrophages in cardiovascular system imaging. To understand the pathological mechanism of cell death in acute myocardial injury through myocardial apoptosis imaging, myocardial necrosis imaging Necrosis of the myocardium and so on.