Background: Rheumatoid arthritis is a kind of chronic systemic autoimmune diseases that invade mainly in articulation. In the early time, it shows wandering pain and dysfunction, and in the late time, it shows stiffness、 deformation of articulation and lose of function. There is no special and nonpoisonous side－ effect effective drug now. Huobahuagen is a kind of special Chinese drug in Southwest, its main ingredients are biological base、 terpines、 lactone、 phenol acid etc. could inhibit inflammatory capillary permeability, decrease exudation and inhibit proliferation.