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食管腺癌和贲门癌是临床上常见的上消化道恶性肿瘤,两者概念不同,又有重叠之处,特别是食管下段腺癌和贲门癌,临床上常需对两者进行鉴别诊断,以指导临床治疗和判断预后,比较两者的异同点有一定意义。鉴定于目前国际上对贲门癌的定义尚无统一的定论,胃食管交界处肿瘤的分类方法较多,根据Siewert的分类方法,食管腺癌和贲门癌的临床特征、淋巴结播散类型、发病机制和某些生物学标记物表达水平均有些不同,最新的检测技术如细胞角质蛋白染色法、Das-1单克隆抗体反应、硫粘蛋白克隆型表达技术等对两者的鉴别价值尚在确定中。
Esophageal adenocarcinoma and cardia cancer are clinically common upper gastrointestinal malignancies, the two concepts are different, there are overlapping places, especially in the lower esophageal adenocarcinoma and cardia cancer, clinically often need to differentiate the two to Guiding clinical treatment and prognosis, comparing the similarities and differences between the two have some significance. According to the classification method of Siewert, the clinical features of esophageal adenocarcinoma and cardia cancer, the type of lymph node dissemination, the pathogenesis And some of the biological markers of expression levels are somewhat different, the latest detection techniques such as cytokeratin staining, Das-1 monoclonal antibody reaction, thionin cloning expression of the differential value of the two is still being determined .