论文部分内容阅读
本文对服用氨甲喋呤的22个病人进行了细胞遗传学研究。作者最初的研究目的是想了解用微核测定来评价氨甲喋呤所引起的遗传物质的损伤是否比骨髓染色体更为敏感。实验组共22个病人,其中一个病人患有多肌炎,其余病人患有普通的牛皮癣。实验共检查了18个病人的骨髓,对其中10个病人的同一骨髓样品进行了细胞遗传学检查和微核测定。并检查了7个病人的外周血淋巴细胞的染色体,染色体检查是在口服或肌注氨甲喋呤以及12～72小时进行的,服药量为
In this article, cytogenetic studies were performed on 22 patients taking methotrexate. The authors’ initial study aimed to understand whether the use of micronucleus assays to evaluate the damage of genetic material caused by methotrexate was more sensitive than bone marrow chromosomes. A total of 22 patients in the experimental group had one patient with polymyositis and the other patients had normal psoriasis. A total of 18 bone marrow samples were examined in the experiment. Cytogenetic and micronucleus measurements were performed on the same bone marrow samples of 10 patients. The chromosomes of peripheral blood lymphocytes from 7 patients were examined. Chromosomal examinations were performed on oral or intramuscular methotrexate and 12 to 72 hours. The dosage was