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本文检测了９４例术前肺癌和３４例术后肺癌血清ＬＳＡ、ＨＣＧ、β_２－ＭＧ和ＣＥＡ的变化。结果表明，肺癌患者这四项指标均较正常人明显升高，以腺癌最突出。术后较术前这四项指标均显著下降，而术后复发者ＨＣＧ、β_２－ＭＧ及ＣＥＡ均明显升高。Ⅰ到Ⅳ期肺癌各指标均逐渐升高。ＬＳＡ对肺癌诊断的敏感性和准确率最高，次为ＨＣＧ、β_２－ＭＧ。腺癌中ＬＳＡ、β_２－ＭＧ的血清水平、敏感性和准确率最高，鳞癌中ＬＳＡ和ＨＣＧ最高，ＳＣＬＣ中ＨＣＧ和β_２－ＭＧ最高。这四项指标的联合检测，有助于肺癌的诊断、鉴别诊断、病情分期及判断术后复发，值得临床深入研究。
This article examined the changes of serum LSA, HCG, β_2-MG and CEA in 94 patients with preoperative lung cancer and 34 patients with postoperative lung cancer. The results showed that these four indicators of lung cancer patients were significantly higher than normal, with the most prominent adenocarcinoma. Postoperatively, these four indexes all decreased significantly, and HCG, β 2 -MG, and CEA significantly increased after recurrence. All indicators of stage I to IV lung cancer gradually increased. LSA has the highest sensitivity and accuracy in the diagnosis of lung cancer, followed by HCG and β_2-MG. The serum levels, sensitivity and accuracy of LSA and β 2 -MG in adenocarcinoma were the highest. LSA and HCG were highest in squamous cell carcinoma, and HCG and β 2 -MG were highest in SCLC. The combined detection of these four indicators is helpful for the diagnosis, differential diagnosis, staging of disease, and postoperative recurrence of lung cancer.