既往诊断坏死性白血病脑病,需赖尸检作脑组织病理学检查证实。近年用计算机X线断层脑扫描(CT)作为一种辅助诊断工具。别的生化指标如乳酸脱氨酶、肌酸磷酸激酶、生长激素和促凝物质活性,也用来指示急淋患者中枢神经系统损害。但对白血病脑病的脱髓鞘特征性病理过程,尚无特异性生化指标。作者按Cohen氏放射免疫方法,对39例急淋患者测定脑脊液中髓磷脂碱性蛋白(MBP)。判断的数值为:<4毫微克/毫升属阴性;4毫微克/毫升为低 Previous diagnosis of necrotic leukemia encephalopathy, requiring autopsy for brain histopathology confirmed. In recent years, computer tomography (CT) as a diagnostic tool. Other biochemical indicators such as lactate deaminase, creatine phosphokinase, growth hormone, and procoagulant activity are also used to indicate CNS damage in acute lymphoid patients. However, demyelination of leukemia encephalopathy characteristic pathological process, there is no specific biochemical indicators. The authors used Cohen’s radioimmunoassay to measure myelin basic protein (MBP) in cerebrospinal fluid in 39 patients with acute lymphoblastic leukemia. Judgments for the value: <4 ng / ml is negative; 4 ng / ml is low