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研究Claudin-4和MMP-2在不同卵巢上皮性肿瘤组织中的表达情况及其意义。方法选择2004～2007年在温州医学院附属二院住院手术治疗、术前未行化疗、放疗的卵巢上皮性肿瘤标本存档蜡块共132例。应用免疫组织化学法检测Claudin-4和MMP-2在正常卵巢组织、卵巢良性上皮性肿瘤组织、卵巢交界性上皮性肿瘤组织、卵巢上皮性癌组织中的表达情况。结果Cladudin-4蛋白和MMP-2蛋白的表达都随着卵巢肿瘤由正常-良性-交界性-癌的发展呈上升趋势(P<0.01)。结论Claudin-4和MMP-2与卵巢上皮性肿瘤细胞恶性转化相关。
To study the expression of Claudin-4 and MMP-2 in different epithelial ovarian tumors and its significance. Methods A total of 132 cases of ovarian epithelial tumor specimens preserved in the Second Affiliated Hospital of Wenzhou Medical College from 2004 to 2007 were selected. Immunohistochemistry was used to detect the expression of Claudin-4 and MMP-2 in normal ovarian tissue, benign epithelial ovarian tumor, borderline ovarian epithelial ovarian tumor and ovarian epithelial carcinoma. Results The expression of Cladudin-4 protein and MMP-2 protein increased with the development of normal-benign-borderline-cancers in ovarian tumors (P <0.01). Conclusions Claudin-4 and MMP-2 are associated with malignant transformation of ovarian epithelial tumor cells.