目的研究消化道应激状态时中枢神经系统的变化。方法应用ＳＤ大鼠结肠内手术埋管，注射三硝基苯碘酸（ＴＮＢＳ）造成应激反应。用免疫组化的方法观察神经细胞ＦＯＳ核蛋白的表达。结果下丘脑室旁核、脑干孤束核、脑桥臂旁核、蓝斑核、腰骶髓的后角、结肠壁的肠肌丛和粘膜下丛神经元中有大量ＦＯＳ核蛋白的出现。结论消化道和中枢神经系统在应激状态中有密切联系。 Objective To study the changes of central nervous system in gastrointestinal stress. Methods SD rats were treated by intracolonic surgery and injected with TNBS to induce stress response. Immunohistochemistry was used to observe the expression of FOS nuclear protein in nerve cells. Results The presence of a large number of FOS nuclear proteins in the paraventricular nucleus of the hypothalamus, solitary tract of the brainstem, parabrachys patens, locus coeruleus, posterior horn of the lumbosacral spinal cord, intestinal myenteric plexus and mucosal plexus neurons in the colon wall. Conclusion The gastrointestinal tract and the central nervous system are closely related to stress state.