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以萘钠为引发剂,以聚乳酸(PDLLA)为疏水链段,聚N-乙烯基吡咯烷酮(PVP)为亲水链段,采用阴离子聚合方法合成了新型P(VP-b-DLLA)两亲型生物降解嵌段共聚物医用高分子材料。通过傅立叶红外光谱(FT-IR)、核磁共振谱(1H-NMR)、热重和元素分析等手段对合成的两亲型嵌段共聚物表征证明了嵌段共聚物的发生,并且得到性能良好的高分子材料。采用透射电镜(TEM)、动态激光光散射(DLS)和荧光分光光度计等技术研究了嵌段共聚物在选择性溶剂中的自组装行为,结果表明所形成胶束具有稳定的结构和适合的药物载体的流体力学直径。
A novel P (VP-b-DLLA) amphiphile was synthesized by anionic polymerization using sodium naphthalene as initiator, polylactic acid (PDLLA) as hydrophobic segment and poly-N-vinylpyrrolidone (PVP) as hydrophilic segment. Biodegradable block copolymer medical polymer materials. Characterization of the synthesized amphiphilic block copolymers by Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance Spectroscopy (1H-NMR), thermogravimetric analysis and elemental analysis proved that the block copolymers were well characterized Of the polymer material. The self-assembly behavior of block copolymers in selective solvents was investigated by transmission electron microscopy (TEM), dynamic laser light scattering (DLS) and fluorescence spectrophotometer. The results show that the micelles have a stable structure and suitable Hydrodynamic diameter of the drug carrier.