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目的用核黄素强化盐对盐亭县居民进行核黄素的补充,评价服用强化盐后的核黄素营养改善情况,为使用强化盐预防食管癌提供依据。方法选取食管癌高发区四川盐亭地区的六个乡所有居民作为研究对象,试验组3万人,对照组3万人。试验组服用核黄素强化盐(核黄素150mg/kg);对照组服用同一批未添加核黄素的普通食盐。采用整群抽样的方法每年分别选取试验组和对照组的部分研究对象,测定红血球谷胱甘肽还原酶活性系数(EGRAC)评价核黄素营养状况。结果1991~1995年共采血1199人份,男性583人份,女性616人份。试验组抽样总体EGRAC平均值为1.09,对照组为1.32,差异具有显著意义,P<0.01。性别和年龄对核黄素的补充均没有影响。结论核黄素强化盐能显著改善核黄素营养状况,是一种经济、简便和有效的营养干预手段。
Objective Riboflavin fortified salt riboflavin supplement Yanting residents to evaluate the use of fortified salt riboflavin nutrition to improve the situation for the use of fortified salt to provide the basis for the prevention of esophageal cancer. Methods All inhabitants of six townships in Yanting, a high incidence area of esophageal cancer, were selected as study subjects, with 30,000 in experimental group and 30,000 in control group. The experimental group took riboflavin enhanced salt (riboflavin 150mg / kg); the control group took the same group of ordinary salt without added riboflavin. The method of cluster sampling was used to select the subjects of the experimental group and the control group respectively, and the activity of erythrocyte glutathione reductase (EGRAC) was measured to evaluate the nutritional status of riboflavin. Results A total of 1199 blood samples were collected from 1991 to 1995, with 583 males and 616 females. The average of EGRAC in the experimental group was 1.09 and that in the control group was 1.32, the difference was significant (P <0.01). Gender and age have no effect on riboflavin supplementation. Conclusion Riboflavin enhanced salt can significantly improve the nutritional status of riboflavin, which is an economical, simple and effective means of nutritional intervention.