Objective: To observe the therapeutic effect of moxibustion, in treatment of diarrhea type Irritable bowel syndrome (IBS). Methods: 56 cases of IBS were divided into treatment group (n=30) and control group (n= 26). Patients of the former group were treated with moxibustion of Guanyuan (CV 4) and Zusanli (ST 36) in combination with Xiajuxu (ST 39) for lowering abdominal pain and with Shangjuxu (ST 37) for left lower abdominal pain; while those of the later group were treated with oral administration of Nifedipinum (10 mg, 3 times a day) end Smecta (1 bag, 3 times daily). After 15 days' treatment, the therapeutic effect was evaluated. Results: After treatment, the effective rates for abdominal pain, abdominal distension, abnormal frequency, abnormal stool, dyspepsia in treatment group were 100.00%, 94.74%, 96.67%, 100.00% and 95. 00% respectively, with a total improving rate of 79. 30%; and those in control group 95.65%, 82.35%, 92.31%, 96.15% and 75.00% separately, with the total improving rate being 63.98%. There were significant differences between two groups in .the effective rate of dyspepsia and the total improving rate of symptoms (P <0. 05, 0. 01). Conclusion: Moxibustion treatment is effective in treatment of IBS and superior to that of Western medicines.