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目的 评价AutoCyteprep液基细胞学 (LCT)薄片制片对宫颈癌筛查的准确性。 方法 2 0 0 3年 8～ 12月广东省东莞市人民医院采用LCT制片及传统宫颈细胞涂片法分别对 4 119例、16 92例受检者进行宫颈癌筛查。细胞诊断采用TBS分级系统 ,阳性诊断包括意义不明的不典型鳞状上皮 (ASCUS)以上病变。所有ASCUS以上病变的受检者全部在阴道镜下活检。结果 LCT薄片法和传统涂片法对ASCUS以上病变的检出率分别为10 5 %、5 2 % ,两者结果差异有显著性意义 (P <0 0 1)。LCT薄片法与病理诊断的阳性符合率为 35 5 % ,显著高于传统涂片法 (2 0 5 % ) ,P <0 0 5。结论 LCT薄片检出ASCUS以上病变阳性率比传统涂片法具有明显优势。液基细胞学的TBS诊断法与阴道镜下定位活检、病理检查结合可以显著提高宫颈癌前病变的准确率。
Objective To evaluate the accuracy of AutoCyteprep liquid-based cytology (LCT) flake screening for cervical cancer screening. Methods From August to December 2003, 4 119 cases and 1692 cases of cervical cancer were screened by LCT and conventional cervical smear respectively in Dongguan People’s Hospital of Guangdong Province. Cell diagnosis using the TBS classification system, positive diagnosis includes atypical unspecified squamous epithelium (ASCUS) lesions above. All subjects with ASCUS lesions were biopsied under colposcopy. Results The positive rates of LCT and traditional smears were 105% and 52% respectively. The differences between the two methods were significant (P <0.01). The positive coincidence rate of LCT and pathological diagnosis was 35.5%, which was significantly higher than that of traditional smear method (20%) (P <0.05). Conclusions The positive rate of LCUS lesions detected by ASCUS is superior to the traditional smear method. Liquid-based cytological TBS diagnosis and colposcopy biopsy, combined with pathological examination can significantly improve the accuracy of cervical precancerous lesions.