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目的:探讨杀伤细胞免疫球蛋白样受体(killer cell immunogloblin-like receptors,KIRs)基因多态性与强直性脊柱炎(ankylosing spondylitis,AS)的关联性。方法:采用序列特异性引物聚合酶链反应(PCR-SSP)法,分析86例AS患者和412例无血缘关系的正常人中迄今发现的14个KIR基因和假基因KIRZ的基因频率、基因型和单倍型。结果:AS患者组活化型KIR3DS1、抑制型KIR2DL2和KIR2DL5的基因频率较对照组显著升高(P<0.05);携带2个或2个以上活化型KIR基因的AS患者明显高于对照人群;其余各KIR的基因频率差异无统计学意义(P>0.05)。结论:活化性/抑制性杀伤细胞免疫球蛋白样受体基因的失衡可能与AS的发生相关。
Objective: To investigate the association between killer cell immunogloblin-like receptors (KIRs) gene polymorphisms and ankylosing spondylitis (AS). Methods: The frequency and genotypes of 14 KIR and KIRZ genes found in 86 AS patients and 412 unrelated healthy individuals were analyzed by PCR-SSP. And haplotypes. Results: The frequencies of KIR3DS1, KIR2DL2 and KIR2DL5 in AS patients were significantly higher than those in controls (P <0.05). The AS patients with two or more KIR genes were significantly higher than those in controls There was no significant difference in the frequency of KIR genes (P> 0.05). CONCLUSION: The imbalance of activated / inhibitory killer cell immunoglobulin-like receptor genes may be related to the occurrence of AS.