茚及其衍生物广泛存在于自然界中,其中多官能团化的茚类化合物大多具有重要的生物活性,因而非常具有成为药物的先导化合物的潜力。特别是茚类化合物的不对称合成吸引了有机化学家们的广泛关注,最近有许多相应的合成方法研究被报道,包括外消旋体拆分、手性辅基及底物诱导的合成和手性催化合成等。本文总结了茚及其衍生物的催化不对称合成研究进展,重点介绍过渡金属及有机小分子不对称催化反应,并对该领域的研究前景进行了展望。 Indene and its derivatives are widely found in nature. Among them, poly-functionalized indene compounds mostly have important biological activity and thus have the potential of becoming leading compounds of drugs. In particular, the asymmetric synthesis of indene compounds has drawn the attention of organic chemists. Recently, many corresponding synthetic methods have been reported, including racemate resolution, chiral prosthetic groups and substrate-induced synthesis and hand Catalytic synthesis. This paper summarizes the progress of catalytic asymmetric synthesis of indene and its derivatives, with emphasis on the asymmetric catalytic reactions of transition metals and small organic molecules, and prospects for the research in this area are also discussed.