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目的探讨血清胆红素与尿酸(UA)检验对冠心病(CHD)患者的临床诊断价值。方法 70例CHD患者设为CHD组,同期70例体检的健康人设为健康组。CHD组根据冠状动脉狭窄程度积分(Gensini)不同划分为四组,即0~1分组(18例),2~20分组(20例),21~40分组(17例)及>40分组(15例)。检测各组血清胆红素及UA水平,观察不同组别研究对象血清胆红素及UA的差异。结果 CHD组UA水平为(403.7±51.6)μmol/L,高于健康组的(268.9±34.8)μmol/L,CHD组血清总胆红素(TBIL)水平为(11.2±1.7)μmol/L、间接胆红素(IBIL)水平为(8.2±2.0)μmol/L、直接胆红素(DBIL)水平为(3.0±0.7)μmol/L,均低于健康组的(14.5±2.8)、(9.1±2.7)、(5.1±1.1)μmol/L,差异均有统计学意义(P<0.05)。21~40分组、>40分组的UA水平高于0~1分组,血清胆红素水平低于0~1分组;>40分组的UA水平高于2~20分组及21~40分组;>40分组的DBIL水平低于2~20分组;差异均有统计学意义(P<0.05)。结论检测血清胆红素与UA水平可辅助临床诊断CHD患者并评估其冠状动脉狭窄的程度,有利于临床治疗与评估预后,值得推广。
Objective To investigate the clinical diagnostic value of serum bilirubin and uric acid (UA) in patients with coronary heart disease (CHD). Methods Seventy patients with CHD were enrolled as the CHD group and 70 healthy subjects were selected as the healthy group. The CHD group was divided into four groups according to the degree of coronary artery stenosis (Gensini): 0 to 1 group (18 cases), 2 to 20 cases (20 cases), 21 to 40 cases (17 cases) and> 40 group example). The levels of serum bilirubin and UA in each group were measured, and the differences of serum bilirubin and UA in different groups were observed. Results The level of UA in CHD group was (403.7 ± 51.6) μmol / L, higher than that in healthy group (268.9 ± 34.8) μmol / L, and the level of total serum TBIL was (11.2 ± 1.7) μmol / L in CHD group Indirect bilirubin level was (8.2 ± 2.0) μmol / L and direct bilirubin level was (3.0 ± 0.7) μmol / L, both of which were lower than those of healthy group (14.5 ± 2.8) and (9.1 ± 2.7), (5.1 ± 1.1) μmol / L, respectively, with statistical significance (P <0.05). UA levels of 21 ~ 40 group and> 40 group were higher than 0 ~ 1 group, serum bilirubin level was lower than 0 ~ 1 group; UA level of> 40 group was higher than that of 2 ~ 20 group and 21 ~ 40 group Group DBIL levels were lower than 2 to 20 groups; differences were statistically significant (P <0.05). Conclusion The detection of serum bilirubin and UA levels can help clinical diagnosis of CHD patients and assess the degree of coronary artery stenosis, is conducive to clinical treatment and prognosis, it is worth promoting.