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目的:评价吴江地区新生儿宫内汞暴露情况及疫苗接种后血汞的变化。方法:选择2009～2010年在吴江市第一人民医院出生的新生儿102例,作脐血汞和胎发汞含量测定,其中38例入住新生儿科病房者,出生时已接种乙肝疫苗,在出生第5 d时做血汞测定。结果:102例新生儿脐血汞平均值为(2.96±1.20)μg/kg,胎发汞平均值为(281.77±113.17)μg/kg,两者呈正相关(r=0.452,P<0.05);38例已接种乙肝疫苗新生儿脐血汞平均值为(2.86±1.57)μg/kg,胎发汞平均值为(279.71±135.79)μg/kg,两者之间呈显著正相关(r=0.486,P<0.05)。38例已接种乙肝疫苗新生儿出生第5 d血汞平均值为(3.06±1.61)μg/kg,与出生时脐血汞比较差异无统计学意义(t=0.55,P>0.05)。结论:吴江地区尚未发现地区性的汞污染。新生儿脐血汞与胎发汞均能比较准确地反映胎儿宫内汞暴露情况,可取其中一项标本检测。新生儿接种乙肝疫苗后血汞水平无显著升高。
Objective: To evaluate the intrauterine mercury exposure in Wujiang area and the changes of blood mercury level after vaccination. Methods: A total of 102 newborns born in the First People’s Hospital of Wujiang City from 2009 to 2010 were selected for the determination of mercury in the umbilical blood and fetal hair. Among them, 38 cases were admitted to the neonatal ward and were born with hepatitis B vaccine. Blood mercury determination was made on the 5th day. Results: The mean of mercury in 102 newborns was (2.96 ± 1.20) μg / kg and the average mercury content was (281.77 ± 113.17) μg / kg in 102 neonates. There was a positive correlation between them (r = 0.452, P <0.05) The mean of mercury in 38 neonates who had been vaccinated with hepatitis B vaccine was (2.86 ± 1.57) μg / kg and that of fetal mercury was (279.71 ± 135.79) μg / kg, with a significant positive correlation (r = 0.486 , P <0.05). Thirty-eight newborns vaccinated with hepatitis B vaccine had mean blood mercury levels (3.06 ± 1.61) μg / kg on the 5th day of birth, which were not significantly different from those at birth (t = 0.55, P> 0.05). Conclusion: No mercury pollution in the area has been found in Wujiang area. Neonatal cord blood mercury and fetal hair mercury can more accurately reflect the intrauterine mercury exposure, desirable one of the specimens tested. Newborns with no significant increase in blood mercury levels after hepatitis B vaccination.