红细胞胆碱酯酶(ChE)活性测定已广泛用于接触有机磷杀虫剂工人的医学监护和中毒诊断。为减少个体间ChE测定值的变异和假阴性结果,作者首次应用可同时测定ChE和Hb的新型仪器作现场调查,并将ChE测定结果用Hb浓度进行校正。研究对象为23名生产六氯苯、DDT和甲基对硫磷的工人,平均年龄36岁,工龄3个月～14年。其中13人(男12、女1)接触有机磷(接触组),另外10名男职工不接触有机磷(对照组)。除询问接触史和中毒史外,用新研制的Testmate型号样机测定ChE和Hb。方法为(1)用酒精棉签擦拭受检者右手拇指2次,取 Determination of erythrocyte cholinesterase (ChE) activity has been widely used for medical monitoring and poisoning of workers exposed to organophosphate insecticides. To reduce variation and false-negative results of ChE determinations among individuals, the authors first applied a field-based study of new instruments capable of simultaneous determination of ChE and Hb, and corrected the ChE assay with Hb concentrations. The study population consisted of 23 workers who produced hexachlorobenzene, DDT and methyl parathion, with an average age of 36 years and a working age of 3 months to 14 years. Thirteen of them (male 12, female 1) were exposed to organophosphorus (contact group) and the other 10 male workers were not exposed to organic phosphorus (control group). In addition to asking for history of exposure and history of poisoning, ChE and Hb were assayed using a newly developed Testmate prototype. Method (1) wipe the right thumb with alcohol cotton swab 2 times, take