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以3-乙氧基-2-环己烯酮羰基邻位芳基化反应与Tsuji-Trost反应的串联反应作为关键步骤来构筑季碳中心,完成了番杏科生物碱Mesembrine的全合成.从商品化原料出发经6步反应以17.8%的总收率合成得到(±)-Mesembrine.
3-ethoxy-2-cyclohexenone carbonyl orthophony reaction and Tsuji-Trost series reaction as the key step to build a quaternary carbon center, complete the Achilles heel alkaloid Mesembrine complete synthesis from The commercially available starting materials were synthesized in 6 steps with 17.8% overall yield (±) -Mesembrine.