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据《科学时报》报道,以中科院院士、上海交通大学教育部微生物代谢重点实验室邓子新教授领衔的研究团队与中科院微生物研究所合作,最近在多氧霉素(又名多抗霉素)生物合成机理研究领域获得突破,从多氧霉素生物合成全基因簇克隆并获得39个候选基因入手,最终确定了20个必需基因,并一举成功实现了多氧霉素在异源宿主中的工程化生产,奠定了代谢工程技术产业化利用的基础。
According to the Science Times, a research team headed by Professor Deng Zixin, a member of the Chinese Academy of Sciences and key laboratory of Microbial Metabolism of the Ministry of Education of Shanghai Jiao Tong University, cooperated with the Institute of Microbiology, Chinese Academy of Sciences recently. In the biosynthesis of polyoxins (also known as polyoxin) A breakthrough was made in the field of mechanism research. Cloning and sequencing of 39 candidate genes from the polythene biosynthesis gene of polyoxins led to the identification of 20 essential genes and the successful engineering of polyoxins in heterologous hosts Production, laid the basis for the industrialization of metabolic engineering technology.