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238医院在应用清栓酶治疗脑血栓病人中发现,病人入院后经用清栓酶0.5μ/10,2-3天后,病人自觉易困,切睡眠时间延长。用药一疗程后(15天)病人基本恢复到正常睡眠.与未用本药前比病人头昏,入睡困难,睡眠时间短等症消失。就此情况我们进行了初步研究和分析.脑干网状结构正中区的中缝核群,边缘系统及大脑皮质的色胺能上行通路,与精神活动有关并具有兴奋和抑制的双重作用,与睡眠觉醒有关。实验证明,中缝核头端的5-羟色胺神经元对慢波睡眠的发生和维持起重要作用,而尾端的5-羟色胺神经元则可引起蓝斑中部和尾部的兴奋,而促发去同步睡眠。这
238 hospitals in the application of thrombolytic enzyme therapy in patients with cerebral thrombosis found that patients admitted to the hospital after the use of clear thrombin 0.5μ / 10,2-3 days, the patient consciously sleepy, cut sleep time. Medication after a course of treatment (15 days) the patient returned to normal sleep with the drug than before the patient than dizziness, difficulty falling asleep, shortness of sleep embolism disappear. In this case, we conducted a preliminary study and analysis of serotonergic upstream pathway in the nucleus raphe nucleus, the limbic system and the cerebral cortex in the central region of the brain stem reticular structure, with the dual role of mental activity and excitement and inhibition, and sleep arousal related. Experiments show that the serratoid nucleus serotonergic neurons play an important role in the occurrence and maintenance of slow wave sleep, and caudal serotonergic neurons can cause the locus ceruleus and caudal excitement, and to promote synchronous sleep. This