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目的观察高血压病人血清一氧化氮（ＮＯ）的水平及药物干预的影响。方法应用比色法测定了３０例正常人和６０例轻中度原发性高血压病人的血清ＮＯ水平，其中５０例高血压病人在应用卡托普利、苯那普利或硝苯地平治疗６周至８周后，复查了血清ＮＯ的浓度。结果高血压病人血清ＮＯ水平较正常对照组明显降低（Ｐ＜０．０１），Ⅱ期病人明显低于Ⅰ期病人（Ｐ＜０．０５），经卡托普利或苯那普利治疗后血清ＮＯ水平明显升高（Ｐ＜０．０５），硝苯地平治疗后无显著变化（Ｐ＞０．０５）。结论高血压病人体内ＮＯ水平显著降低，卡托普利或苯那普利治疗后ＮＯ水平明显升高。提示ＮＯ在高血压病的发生发展中有一定的作用。
Objective To observe the level of serum nitric oxide (NO) in hypertensive patients and the effect of drug intervention. Methods Serum NO levels were measured by colorimetry in 30 normal subjects and 60 patients with mild to moderate essential hypertension. Fifty patients with hypertension were treated with captopril, benazepril or nifedipine After 6 weeks to 8 weeks, the serum NO concentration was examined. Results The level of serum NO in hypertensive patients was significantly lower than that in the control group (P <0.01), and the level of NO in stage Ⅱ patients was significantly lower than that in stage Ⅰ patients (P <0.05). After treatment with captopril or benazepril Serum NO levels were significantly increased (P <0.05), nifedipine no significant change after treatment (P> 0.05). Conclusions The level of NO in patients with essential hypertension is significantly reduced, and the level of NO is significantly increased after treatment with captopril or benazepril. Tip NO in the occurrence and development of hypertension has a certain role.