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目的:探讨中药丹红注射液在急性缺血性脑卒中患者中的临床应用价值和意义。方法:选取2013年6月—2014年6月期间本院收治的急性缺血性脑卒中患者90例,将其随机分为研究组和对照组,每组45例。对照组患者给予脱水降颅压、抗血小板聚集、脑保护剂等一般常规治疗方案,研究组患者则在对照组基础上采用中药丹红注射液的临床药物治疗,分别比较和分析两组患者的神经功能恢复情况、血液流变学变化情况及日常生活能力改善情况。结果:与对照组相比,研究组患者神经功能显著进步的比率46.67%(21/45)和总有效率91.11%(41/45)均显著提高,并且两组间比较差别均具有统计学意义(P<0.05);研究组患者治疗后血浆黏度(1.39±0.21)m Pa·s,全血黏度高切值(5.91±0.12)m Pa·s,全血黏度低切值(7.18±1.34)m Pa·s,红细胞压积(40.23±4.15)%,血小板黏附率(26.73±5.24)%等血液流变学指标均显著降低,并且两组间比较差别均具有统计学意义(P<0.05);研究组患者治疗后BI评分值(74.61±7.82)分和FMA评分值(54.88±5.36)分均显著提高,并且两组间比较差别均具有统计学意义(P<0.05)。结论:中药丹红注射液对于急性缺血性脑卒中患者神经功能的恢复,血液流变学的改善以及日常生活能力的提升均具有极其重要的临床治疗意义,值得进一步的应用和推广。
Objective: To investigate the clinical value and significance of Chinese traditional medicine Danhong injection in acute ischemic stroke patients. Methods: Totally 90 acute ischemic stroke patients admitted in our hospital from June 2013 to June 2014 were randomly divided into study group and control group, with 45 cases in each group. Patients in the control group were given conventional regimens of dehydration and intracranial pressure, anti-platelet aggregation and brain protective agent. Patients in the study group were treated with Danhong injection of traditional Chinese medicine on the basis of the control group, and were compared and analyzed respectively Neurological recovery, changes in hemorheology and improvement of daily living ability. Results: Compared with the control group, the rate of neurological improvement significantly increased in 46.67% (21/45) and 91.11% (41/45) in the study group, and the differences between the two groups were statistically significant (P <0.05). After treatment, the plasma viscosity (1.39 ± 0.21) mPa · s, the high whole blood viscosity (5.91 ± 0.12) mPa · s and the low whole blood viscosity (7.18 ± 1.34) hemorheology indexes such as mPa · s, hematocrit (40.23 ± 4.15)%, platelet adhesion rate (26.73 ± 5.24)% were significantly decreased, and the difference between the two groups was statistically significant (P0.05) The score of BI (74.61 ± 7.82) and FMA (54.88 ± 5.36) in the study group were significantly increased after treatment, and the differences between the two groups were statistically significant (P <0.05). Conclusion: The traditional Chinese medicine Danhong injection has important clinical significance for the recovery of neurological function, improvement of hemorheology and ability of daily living in patients with acute ischemic stroke, which is worthy of further application and promotion.