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目的:探讨Livin、血管内皮生长因子(VEGF)在甲状腺癌中的表达与临床病理因素的关系。方法:采用免疫组织化学EnVison两步法检测70例甲状腺癌、18例甲状腺瘤及18例正常甲状腺组织中Livin、VEGF的表达,并对其与性别、年龄、肿瘤大小、病理学分型、临床分期及淋巴结转移的关系进行分析。结果:70例甲状腺癌中Livin、VEGF的阳性率分别为65.7%、61.4%,与甲状腺瘤、正常甲状腺组织相比较差异有统计学意义(P<0.05)。甲状腺癌中Livin、VEGF的表达在不同病理类型、临床分期、淋巴结转移相比较差异有统计学意义(P<0.05)。经Spearman等级相关性分析表明,Livin与VEGF的表达呈正相关(r=0.484,P<0.001)。结论:Livin和VEGF的异常表达与甲状腺癌的发生发展有关,可作为甲状腺癌预后的参考指标。
Objective: To investigate the relationship between the expression of Livin and vascular endothelial growth factor (VEGF) in thyroid carcinoma and the clinicopathological factors. Methods: The expressions of Livin and VEGF in 70 cases of thyroid cancer, 18 cases of thyroid tumor and 18 cases of normal thyroid tissue were detected by immunohistochemistry EnVison two-step method, and their relationship with sex, age, tumor size, pathological type, clinical stage And lymph node metastasis were analyzed. Results: The positive rates of Livin and VEGF in 70 thyroid carcinomas were 65.7% and 61.4%, respectively, which were significantly different from those of thyroid tumors and normal thyroid tissues (P <0.05). The expression of Livin and VEGF in thyroid carcinoma was significantly different in different pathological types, clinical stage and lymph node metastasis (P <0.05). Spearman rank correlation analysis showed that the expression of Livin and VEGF was positively correlated (r = 0.484, P <0.001). Conclusion: The abnormal expression of Livin and VEGF is associated with the occurrence and development of thyroid cancer and may be used as a reference index for the prognosis of thyroid cancer.