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宫颈癌是全球女性第二常见的恶性肿瘤,每年报告新发病人数约为50万例,死亡约25万例~[1],而我国每年新增宫颈癌病例超过13万,约占全世界报告新发宫颈癌病例数的1/4~[2]。宫颈癌的发病机制目前尚不十分清楚,其发生往往是一个多因素、多步骤作用的综合结果。高危型人乳头瘤病毒(high risk human papillomavirus,hr HPV)持续感染已是公认的宫颈癌主要致病因素~[3]。然而,并不是感染HPV
Cervical cancer is the second most common malignant tumor among women in the world. The annual number of new cases of cervical cancer is about 500,000 and the death rate is about 250,000. [1] However, there are more than 130,000 new cases of cervical cancer in our country each year, accounting for about the world’s reports The number of new cases of cervical cancer 1/4 ~ [2]. The pathogenesis of cervical cancer is not yet clear, and its occurrence is often a multi-factor, multi-step combination of the results. Persistent infection with high-risk human papillomavirus (hr HPV) has been recognized as a major causative factor for cervical cancer [3]. However, it is not HPV infection