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目的 研究瘤内单纯注射3 2 P胶体和先注射聚合白蛋白 (MAA) ,再注射3 2 P胶体两种不同给药方法的3 2 P在肿瘤组织和血液及各器官的动态分布 ,探讨MAA减少肝癌组织内3 2 P胶体血行扩散的作用。方法 在Balb/c小鼠右侧胸前皮下接种H2 2 肝癌细胞 ,10天后接种部位长出直径约 1cm的肿瘤。随机将其分为 2组 :第 1组只注射3 2 P胶体 1.85MBq ;第 2组先注射 1× 10 5颗粒MAA ,再注射3 2 P胶体 1.85MBq。注射后的第 30分钟、2 4小时、48小时、第 8天和第 16天时处死小鼠 ,测定肿瘤组织、血液和心、肝、肾、肺、骨骼的放射性。结果 瘤内注射3 2 P胶体时 ,肿瘤内的放射性随时间延长而下降 ,但注射MAA组的放射性下降速度较未注射组明显延缓 ;而其他器官的放射性 ,注射MAA组较未注射组明显减少。结论 与单纯瘤内注射3 2 P胶体相比 ,先在瘤内注入MAA ,再注入3 2 P胶体 ,MAA可以有效阻止3 2 P胶体的全身扩散 ,使3 2 P胶体能够较长时间的滞留在肿瘤内 ,减少了全身分布。
Objective To investigate the dynamic distribution of 3 2 P in tumor tissue, blood and various organs in mice injected with 3 2 P colloids and MAA injection followed by 3 2 P colloid injections. To investigate the effects of MAA Reduce the role of 3 2 P colloid blood circulation in hepatocellular carcinoma tissue. Methods Balb / c mice were inoculated subcutaneously on the right chest with H2 2 hepatoma cells. After 10 days, the tumors were seeded with a diameter of about 1 cm. Randomly divided into two groups: Group 1 injection of only 3 2 P colloid 1.85MBq; Group 2 injection of 1 × 10 5 particles of MAA, and then injected 3 2 P colloid 1.85MBq. Mice were sacrificed at 30 minutes, 24 hours, 48 hours, 8 days and 16 days after injection, and radioactivity in tumor tissues, blood and heart, liver, kidney, lung and bone was measured. Results In the intratumoral injection of 3 2 P colloid, radioactivity in the tumor decreased with time, but the radioactive decline rate in the MAA injection group was significantly delayed than that in the non-injection group; while radioactivity in other organs and MAA injection group were significantly decreased compared with the non-injection group . CONCLUSION: Compared with the intratumoral injection of 3 2 P colloids, MAA can be injected intratumorally and injected with 3 2 P colloids, MAA can effectively prevent the systemic spread of 3 2 P colloids and allow the retention of 3 2 P colloids for a long time Within the tumor, reduced systemic distribution.