收集 4～ 14岁胰岛素依赖型糖尿病 (IDDM, 型 )患儿 15例 ,并按性别、年龄配对调查正常儿童 15例。分别测定其血浆内皮素 (ET)、6 -酮 -前列环素 (6 - K- PGF1α)及血清一氧化氮 (NO)水平 ,测量其收缩压 (SBp)和舒张压 (DBp)。结果 :糖尿病组的 ET、SBp较正常对照组升高 ,而 NO、6 - K- PGF1α降低 ,差异有显著性意义 (P均 <0 .0 5 )。糖尿病组 DBp也略有升高 ,但较对照组差异无显著性意义。提示糖尿病患儿的血管内皮分泌功能紊乱 ,其内皮源性松弛因子减少 ,收缩因子增加 ,从而导致 SBp、DBp升高。 15 children aged 4-14 years old with insulin-dependent diabetes mellitus (IDDM) were collected and 15 normal children were investigated by gender and age. Plasma ET, 6 - keto - prostacyclin (6 - K - PGF1α) and serum nitric oxide (NO) levels were measured and the systolic blood pressure (SBp) and diastolic blood pressure (DBp) were measured. Results: The levels of ET and SBp in diabetic group were higher than those in normal control group, while NO and 6 - K - PGF1α were decreased (P <0.05). DBp in diabetic group also slightly increased, but no significant difference compared with the control group. Prompt vascular endothelial dysfunction in children with diabetes, endothelium-derived relaxation factor decreased, increased contraction factor, resulting in SBp, DBp increased.