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目的:探析丙型肝炎采用肝脏酶谱、抗-HCV抗体以及血清HCV-RNA诊断的临床效果。方法:选择2014年9月至2016年7月河源市人民医院收治的丙型肝炎患者132例作为观察组,选择同期来本院体检的健康者60例为对照组,分别检测两组的γ-GT、AST、ALT、抗-HCV抗体滴度以及HCV-RNA水平,并对两组的检测结果进行比较分析。结果:在观察组132例患者中,同时检测抗HCV抗体滴度和HCV-RNA定量诊断的阳性率为81.06%(107/132),说明抗-HCV抗体滴度和HCV-RNA定量不存在明显相关性(P>0.05);而HCV-RNA水平与γ-GT、AST以及ALT水平则存在明显的相关性(P<0.05);观察组与对照组的ALT、AST以及γ-GT水平比较差异有统计意义(P<0.05)。结论:临床上在诊断丙型肝炎时,同时检测抗-HCV抗体滴度和HCV-RNA定量能够显著提高检出率。肝脏酶谱的检测,可对肝脏受损状况进行评估,为治疗和判断预后提供有效依据。
Objective: To investigate the clinical effect of hepatitis C virus spectrum, anti-HCV antibody and serum HCV-RNA diagnosis. Methods: From September 2014 to July 2016, Heyuan Municipal People’s Hospital of Hepatitis C patients treated 132 cases as the observation group, select the same period to our hospital physical examination 60 cases as control group, were detected in both groups γ- GT, AST, ALT, anti-HCV antibody titers and HCV-RNA levels, and compared the test results of the two groups. Results: In the observation group of 132 patients, simultaneous detection of anti-HCV antibody titers and HCV-RNA quantitative diagnosis of the positive rate was 81.06% (107/132), indicating anti-HCV antibody titers and HCV-RNA quantitative no significant (P> 0.05). There was a significant correlation between HCV-RNA level and γ-GT, AST and ALT levels (P <0.05). The levels of ALT, AST and γ-GT in the observation group and the control group were significantly different There was statistical significance (P <0.05). Conclusions: In the clinical diagnosis of hepatitis C, simultaneous detection of anti-HCV antibody titer and HCV-RNA quantification can significantly improve the detection rate. Liver enzyme detection, liver damage can be assessed for the treatment and prognosis to provide an effective basis.