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目的探讨氟西汀联合心理干预对帕金森病患者情绪障碍的疗效。方法将符合CCMD-3抑郁症诊断标准的帕金森病50例患者随机分成两组。研究组在抗帕金森病药物基础上联合氟西汀20mg/d和心理干预治疗,对照组仅用抗帕金森病药物治疗,疗程8周。采用汉密顿抑郁量表(HAMD)评定疗效。结果经8周治疗后,研究组显效率为80.0,对照组为32.0,两组之间有显著性差异(P<0.01),研究组比对照组抑郁评分下降显著(P<0.05),两组间HAMD减分率于第2、4、8周末比较均有显著性差异(P<0.05～0.01)。结论氟西汀联合心理干预对帕金森病患者情绪障碍具有良好疗效,而且副反应没有明显增加。
Objective To investigate the efficacy of fluoxetine combined with psychological intervention on mood disorders in patients with Parkinson’s disease. Methods Fifty patients with Parkinson’s disease who met the diagnostic criteria of CCMD-3 depression were randomly divided into two groups. The study group was treated with fluoxetine 20mg / d on the basis of anti-Parkinson’s disease drugs and psychological intervention, while the control group was treated with anti-Parkinson’s disease only for 8 weeks. The Hamilton Depression Rating Scale (HAMD) was used to assess the efficacy. Results After 8 weeks of treatment, the effective rate was 80.0% in the study group and 32.0% in the control group, with significant difference between the two groups (P <0.01). The depression score of the study group was significantly lower than that of the control group (P <0.05) The reduction rate of HAMD between the two groups had significant difference at the end of the 2nd, 4th and 8th week (P <0.05 ~ 0.01). Conclusions Fluoxetine combined with psychological intervention has a good curative effect on mood disorders in patients with Parkinson’s disease, and the side effects are not significantly increased.