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急性白血病常出现口腔溃疡,临床表现为口腔剧烈疼痛,易合并感染,影响患者治疗及预后。沙利度胺有抑制血管生成、有效阻断TNF-α,调节免疫功能及影响微环境中细胞因子的释放~〔1〕,目前被广泛用于多发性骨髓瘤、淋巴瘤、骨髓增殖性疾病乃至急性白血病的治疗,亦用于白塞氏病等多种自身免疫性疾病和复发性口腔溃疡等疾病的治疗~〔2〕。我们在前期临床观察中发现沙利度胺对急性白血病患者口腔溃疡有明显的疗效,遂进一步研究,现
Acute leukemia often appear oral ulcers, the clinical manifestations of severe oral pain, easy to merge infection, affecting patient treatment and prognosis. Thalidomide can inhibit angiogenesis, effectively block TNF-α, regulate immune function and affect the release of cytokines in the microenvironment. [1] It is widely used in multiple myeloma, lymphoma, myeloproliferative diseases As well as the treatment of acute leukemia, but also for Behcet’s disease and other autoimmune diseases and recurrent oral ulcers and other diseases treatment 〔2〕. We found in the preliminary clinical observation that thalidomide has a significant effect on oral ulcer in patients with acute leukemia, and further study, and now