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目的探讨原发性肝细胞癌患者体内β-葡萄糖醛酸酶（β-G）变化现规律。方法采用ELISA法、免疫组化法对31例原发性肝细胞癌患者血清肤癌组中β-G进行同步研究，并对其中10例进行免疫电镜研究。结果β-G在肝癌患者血清及癌组织中部呈过度表达，与对照组有非常显著性差异（P＜0.01）。结论对β-G机能学及形态学的联合检测，可能成为肝癌诊断的辅助指标。
Objective To investigate the changes of β-glucuronidase (β-G) in patients with primary hepatocellular carcinoma. Methods ELISA and immunohistochemistry were used to study the β-G in serum from 31 cases of primary hepatocellular carcinoma patients. Immunoelectron microscopy was performed in 10 of them. Results β-G was over-expressed in serum and cancer tissues of patients with hepatocellular carcinoma, and it was significantly different from that in the control group (P<0.01). Conclusion Joint detection of β-G function and morphology may be an auxiliary indicator for the diagnosis of liver cancer.